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KMID : 0191120130280040555
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Journal of Korean Medical Science
2013 Volume.28 No. 4 p.555 ~ p.563
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Elevation of Morning Blood Pressure in Sodium Resistant Subjects by High Sodium Diet
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Rhee Moo-Yong
Lim Chi-Yeon
Shin Sung-Joon
Oh Sang-Woo
Park Yong-Soon
Kim Jong-Wook
Park Hye-Kyoung
Kim Cho-Il
Park Cheol-Young
Kim Sun-Woong
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Abstract
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The present study evaluated the response of blood pressure (BP) by dietary sodium in sodium resistant (SR) subjects. One hundred one subjects (mean age, 46.0 yr; 31 hypertensives) were admitted and given low sodium-dietary approaches to stop hypertension (DASH) diet (LSD, 100 mM NaCl/day) for 7 days and high sodium-DASH diet (HSD, 300 mM NaCl/day) for the following 7 days. On the last day of each diet, 24 hr ambulatory BP was measured. Morning systolic BP (SBP) and diastolic BP (DBP) were elevated after HSD in all subjects (P < 0.01), but daytime SBP and DBP were not changed (P > 0.05). In hypertensive subjects, morning DBP elevation was greater than daytime DBP elevation (P = 0.036), although both DBPs were significantly elevated after HSD. The augmented elevation of morning DBP in hypertensive subjects was contributed by the absolute elevation of morning DBP (P = 0.032) and relative elevation to daytime DBP (P = 0.005) in sodium resistant (SR) subjects, but not by sodium sensitive subjects. Although there was no absolute elevation, SR subjects with normotension showed a relative elevation of morning SBP compared to daytime SBP change after HSD (P = 0.009). The present study demonstrates an absolute and relative elevation of morning BP in SR subjects by HSD.
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KEYWORD
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Sodium, Hypertension, Sodium Resistance
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